Naar de werking van Choline bij ouderdomsklachten, ook bij hond en kat, zijn diverse studies verricht:
Choline loading: Specific dietary supplementation for modifying neurologie and behavorial disorders in dogs and cats. Vet Med/Small Animal Clinician, Aug 1982: 1223-1231.
Richard C. Tees*, Ehsan Mohammadi. The effects of neonatal choline dietary supplementation on adult spatial and configural learning and memory in rats. Developmental Psychobiology, 1999, Volume 35, Issue 3 , Pages 226 – 240.
Gowri K. Pyapali, Dennis A. Turner, Christina L. Williams, Warren H. Meck, and H. Scott Swartzwelder. Prenatal Dietary Choline Supplementation Decreases the Threshold for Induction of Long-Term Potentiation in Young Adult Rats. The Journal of Neurophysiology, Vol. 79 No. 4 April 1998, pp. 1790-1796.
Perry EK, Gibson PH, Blessed G, Perry RH, Tomlinson BE. Neurotransmitter enzyme abnormalities in senile dementia. Choline acetyltransferase and glutamic acid decarboxylase activities in necropsy brain tissue. Journal of Neurological Science, 1977 Nov;34(2):247-65.